You may be familiar with various cancer treatments available and how two or more treatments are used to form a more robust approach to fighting cancer. Radiotherapy is used to kill cancer cells and arrest tumor growth directly. Radiotherapy may also be coupled with chemotherapy where chemical substances are used to slow down or stop cancer cell growth.
You may also know how
cancer treatment is perhaps one of the most challenging forms of therapy for a
patient to go through. Understanding how cancer works is important
for any person that may need to undergo any kind of cancer treatment. Cancer
treatment is not a straight road to cancer cure and patients may go through
several complications or secondary ailments due to the effects of cancer
treatment. Cancer care becomes an extremely important
area of concern for addressing secondary infections to cancer treatment. In
this article we explore a common condition seen amongst cancer patients that
suffer from cancers from the head to the neck region.
What is Radiation induced mucositis
Radiation mucositis is
also referred to as radiation-induced oral mucositis. It is an acute injury to
the mucosal lining of any part of the alimentary canal due to radiation or
chemotherapy or both. The alimentary canal refers to all the organs that food
needs to pass through from ingestion, digestion, absorption and excretion. This
covers the mouth, throat, esophagus, stomach, intestines, rectum and anus. The
cells in the body’s mucous membrane are similar to cancer cells in that they
too divide rapidly. Radiotherapy and chemotherapy are designed to attack
exactly these types of cells and thus the mucous membrane gets damaged
Stages of radiation mucositis
The development of
radiation mucositis is complex and involves more than just the damage of the
mucous membrane of a site of the alimentary canal. The development of mucositis
can be divided into five phases:
Initiation: Radiation begins to cause cellular damage to epithelial cells. The damage, however, is still not noticeable.
Signaling: In response to the cellular damage, signals are sent from the surface to the insides of the cell. This leads to inflammation and cell death that now start to present itself as mucosal ulcers. A pseudomembrane, consisting of bacteria, covers the ulcers.
Amplification and
ulceration: Colonizing bacteria and pro-inflammatory proteins begin to
infiltrate the submucosa which amplifies direct and indirect cell damage. This
feedback loop causes increased inflammation and tissue damage.
Healing: Characterised by
the extent of mucosal damage, healing time may vary. Healing can also vary
depending on secondary infections and some deep ulcers may never heal and
result in soft tissue necrosis.
The challenges and danger of radiation mucositis
Nearly all patients, upto
97%, receiving radiation therapy in the head or neck region develop some extent
of mucositis. Of these patients, atleast one-third suffer from a severe form of
mucositis. Mucositis affects cancer treatment and the patient’s level of
comfort to a great extent. As mucositis progresses, it puts an interruption to
cancer treatment in order to control mucositis. This affects the cancer
treatment plan and often allows tumor growth. Mucositis also increases the need
for giving patients nutrition intravenously. The effects of mucositis are best
understood through a review of the symptoms of radiation mucositis.
Symptoms of radiation mucositis
Some physical symptoms of
oral mucositis include red gums, white patches on the tongue, painful sores in
the mouth and throat, bad breath and blood in the mouth. Many patients also
have dry mouth that severely affects their appetite and causes nausea and
gagging.
Patients with severe
mucositis also have trouble swallowing due to the pain and inflammation. Some
other symptoms include bloating, diarrhea or constipation. Blood may be found
in feces and ulcers may occur around the rectum and anus.
Secondary infections and other complications
Mucositis increases the risk
of secondary infections from viruses, bacteria or fungi. Septicemia is one such
bacterial infection of the blood that can create several complications for the
patient and requires the doctor’s immediate attention. Apart from infections,
nutritional deficiencies may develop due to the patient’s loss of appetite and
difficulty swallowing and digesting food. This can become very challenging for
a cancer patient whose nutritional requirements are vital.
Management of radiation mucositis
Currently, doctors take
steps to reduce the risks of radiation mucositis or employ symptomatic
treatment to manage mucositis. Managing mucositis is a multidisciplinary
approach that tries to protect or alleviate pain at various sites of cell
damage.
Reducing risks of mucositis
Oral hygiene practices
play an important role in reducing the risk of mucositis. However, in the case
of mucositis, there may be several considerations to keep in mind to properly
ensure oral care and hygiene. This includes using a fluoride toothpaste,
frequent rinsing of the mouth with a saline solution, brushing more frequently
with a soft brush, flossing, taking antimicrobial lozenges, etc.
Pain management
Pain management is
extremely important as it affects the nutritional intake of the patient as
well. Pain management may see a combination of topical and systemic analgesics.
Systemic pain treatment may include oral narcotics that a doctor will evaluate
continuously. Other methods may include eating ice chips and taking cold foods.
Topical analgesics may include mucaine gels.
Nutritional support
Patients suffering from
mucositis not only experience pain that affects their appetite, but also
experience changes in taste. Continuous weight monitoring is required with a
dietician frequently discussing the patient’s diet and exploring foods that are
agreeable. In very severe cases, the patient may totally rely on parenteral
nutrition which refers to nutrition that is completely provided intravenously.
Managing symptoms of dry mouth
Patients suffering from mucositis frequently complain of dry mouth which is the oversecretion of saliva in the mouth and throat. Salt and soda solutions are helpful in the initial stages of dry mouth. Doctors may resort to other stronger forms of medications as symptoms progress.
If you or someone you know
is receiving radiotherapy for cancer and you are concerned about radiation
induced mucositis, you can speak to our experienced oncologists who can
talk you through the strategies they employ during cancer treatment to prevent
and mitigate symptoms of radiation induced mucositis. The Oncology
Department at the Park Group of Hospitals is well renowned and is
equipped to cater to end-to-end cancer care and treatment.
Conclusion
Radiation induced
mucositis is a dose-limiting toxicity in the case of cancer patients
radiotherapy in the head and neck region. It affects the approach to cancer
treatment in such patients, as well as increases the discomfort of the cancer
patient to the extreme where the patient can no longer consume nutrition. While
there may be strategies to reduce the risk of mucositis and manage the pain
caused by it, there is yet to be found an adequate approach to fully mitigate
the risks and effects of radiation mucositis.
FAQ
1.
Is radiation mucositis treatable?
Yes.
Radiation mucositis, which is an inevitable side effect of radiotherapy in
patients receiving treatment for cancer in the head and neck region, can be
treated using several different approaches and heals once cancer treatment is
completed.
2.
Is radiation mucositis common
amongst cancer patients?
Ninety
seven percent of cancer patients receiving radiotherapy in the head and neck
region contract some level of mucositis. One-third of these patients can expect
to suffer from a severe case of mucositis.
3.
How does my oncologist detect if
I have radiation mucositis?
Oncologists
will keep a close eye on all side effects that can be expected from
radiotherapy and chemotherapy. Ulcers are a common symptom of mucositis.
Oncologists also use a variety of scales like the WHO oral toxicity scale.
4.
How can I prevent radiation
mucositis?
If you
are a cancer patient receiving radiotherapy in the head or neck region, you are
highly susceptible to contract mucositis. However, good oral care can reduce
the risks of mucositis. Radiation induced mucositis cannot be fully prevented
in this scenario.
5.
How does radiation mucositis
affect cancer treatment?
When
mucositis becomes severe and the patient’s nutrition and pain levels reach a
concerning level, cancer treatment may need to be interrupted to allow the
healing of the mucous membrane. Oncologists may also need to limit radiotherapy
dosage so as to delay or prevent the onset of radiation induced mucositis.
6.
What are some other conditions
associated with radiation mucositis?
The most
common conditions associated with mucositis are dry mouth which causes nausea,
gagging and difficulty swallowing, and secondary infections like septicemia
which is an infection in the blood. Both cause considerable complications that
oncologists take into account while treating radiation induced mucositis.